Tissue regeneration has become a promising treatment for craniomaxillofacial bone defects such as alveolar clefts. This study sought\nto assess the efficacy of lateral ramus cortical plate with buccal fat pad derived mesenchymal stem cells (BFSCs) in treatment of\nhuman alveolar cleft defects. Ten patients with unilateral anterior maxillary cleft met the inclusion criteria and were assigned to\nthree treatment groups. First group was treated with anterior iliac crest (AIC) bone and a collagen membrane (AIC group), the\nsecond group was treated with lateral ramus cortical bone plate (LRCP) with BFSCs mounted on a natural bovine bone mineral\n(LRCP+BFSC), and the third group was treated with AIC bone, BFSCs cultured on natural bovine bone mineral, and a collagen\nmembrane (AIC+BFSC). The amount of regenerated bone was measured using cone beam computed tomography 6 months\npostoperatively. AIC group showed the least amount of new bone formation (70 �± 10.40%). LRCP+BFSC group demonstrated\ndefect closure and higher amounts of new bone formation (75 �± 3.5%) but less than AIC+BFSC (82.5 �± 6.45%), suggesting that use\nof BFSCs within LRCP cage and AIC may enhance bone regeneration in alveolar cleft bone defects; however, the differences were\nnot statistically significant. This clinical trial was registered at clinicaltrial.gov with NCT02859025 identifier.
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